| 14/08/2021 | V Leeds | Home | Premier League |
| 22/08/2021 | V Southampton | Away | Premier League |
| 29/08/2021 | V Wolves | Away | Premier League |
| 11/09/2021 | V Newcastle | Home | Premier League |
| 14/09/2021 | V BSC Young Boys Bern | Away | Champions League |
| 19/09/2021 | V West Ham | Away | Premier League |
| 22/09/2021 | V West Ham | Home | Carabao Cup |
| 25/09/2021 | V Aston Villa | Home | Premier League |
| 29/09/2021 | V Villarreal | Home | Champions League |
| 02/10/2021 | V Everton | Home | Premier League |
| 16/10/2021 | V Leicester City | Home | Premier League |
| 20/10/2021 | V Atalanta | Home | Champions League |
| 24/10/2021 | V Liverpool | Home | Premier League |
| 30/10/2021 | V Tottenham | Away | Premier League |
| 02/11/2021 | V Atalanta | Away | Champions League |
| 06/11/2021 | V Man City | Home | Premier League |
| 20/11/2021 | V Watford | Away | Premier League |
| 23/11/2021 | V Villarreal | Away | Champions League |
| 27/11/2021 | V Chelsea | Away | Premier League |
| 30/11/2021 | V Arsenal | Home | Premier League |
| 04/12/2021 | V Crystal Palace | Home | Premier League |
| 08/12/2021 | V BSC Young Boys Bern | Home | Champions League |
| 11/12/2021 | V Norwich | Away | Premier League |
| 14/12/2021 | V Brentford | Away | Premier League |
| 18/12/2021 | V Brighton | Home | Premier League |
| 26/12/2021 | V Newcastle | Away | Premier League |
| 28/12/2021 | V Burnley | Home | Premier League |
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